In which cells of vertebrates are mutations the most dangerous for posterity ?

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Mutations in the germline cells of vertebrates are the most dangerous for posterity. Germline cells give rise to gametes (sperm and eggs) and are involved in the transmission of genetic material from one generation to the next. Mutations in germline cells can be passed on to offspring, potentially leading to genetic disorders or other negative consequences in future generations. Mutations in somatic cells, on the other hand, typically only affect the individual in which they occur and are not passed on to future generations.