22 + 2 - 2 + 3 + 7 - 5 + 45632 - 357 + 1000
= 4 + 2 - 2 + 3 + 7 - 5 + 9126 - 357 + 1000
= 6 - 2 + 3 + 7 - 5 + 9126 - 357 + 1000
= 4 + 3 + 7 - 5 + 9126 - 357 + 1000
= 7 + 7 - 5 + 9126 - 357 + 1000
= 14 - 5 + 9126 - 357 + 1000
= 9 + 9126 - 357 + 1000
= 9135 - 357 + 1000
= 8778 + 1000
= 9778

Therefore, the result of the expression is 9778.