Starting by distributing the terms in the first parentheses:

= -8x^2(5x + 8)(6x^2 + 5)

= -8x^2(5x)(6x^2 + 5) - 8x^2(8)(6x^2 + 5)

Next, distribute the terms inside the parentheses:

= -40x^3(6x^2 + 5) - 40x^2(6x^2 + 5)

Now distribute the -40x^3 and -40x^2 terms:

= -240x^5 - 200x^3 - 240x^4 - 200x^2

Combining like terms:

= -240x^5 - 240x^4 - 200x^3 - 200x^2

Final answer: -240x^5 - 240x^4 - 200x^3 - 200x^2