To simplify the expression, we need to combine like terms:

4x - 3/3 - 2x - 4 + 5x/3 + 2x - 3 + x - 10x^2 / 4x^2 - 9

First, simplify the numerical values within the expression:

4x - 1 - 2x - 4 + 5x/3 + 2x - 3 + x - 10x^2 / 4x^2 - 9

Next, combine like terms:

(4x - 2x + 5x/3 + 2x + x) - 1 - 4 - 3 - 3 - 10x^2 / 4x^2 - 9

9x + 5x/3 - 11 - 10x^2 / 4x^2 - 9

To simplify further, we can find a common denominator for the terms with fractions:

(27x / 3) + 5x/3 - 11 - 10x^2 / 4x^2 - 9

(27x + 5x) / 3 - 11 - 10x^2 / 4x^2 - 9

(32x/3) - 11 - 10x^2 / 4x^2 - 9

Lastly, we can simplify the expression even further:

(32x - 33 - 10x^2 / 4x^2)

Therefore, the simplified expression is (32x - 33 - 10x^2 / 4x^2).