2\х-4 - х+8\х^2-16 -1\х

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To simplify the expression, we need to combine like terms.

First, let's combine the terms with x:

2x - x = x
-4 - 8 = -12
x^2 - 16 is a difference of squares, so it can be factored as (x+4)(x-4).

Putting it all together, we get:
x - 12 / (x+4)(x-4)